H Score Hlh

Singer hemophagocytic lymphohistiocytosis and other culture negative sepsis like syndromes in the icu evidence based critical care 10 1007 978 3 030 26710 0 591 598 2020.

H score hlh. Developed the h score a probability model based on data collected from a multicenter adult cohort with secondary hlh. A multicenter retrospective cohort of 312 patients who were judged by experts to have reactive hemophagocytic syndrome n 162 were judged by experts to not have reactive hemophagocytic syndrome n 104 or in whom the. Agreement between h score and hlh 2004 guidelines in undetermined cases. Score issued from the manuscript development and validation of a score for the diagnosis of reactive hemophagocytic syndrome hscore by l fardet l galicier o lambotte et col.

The actual diagnostic criteria for hlh henter et al. The h score has been shown to perform better than the hlh 2004 criteria if used at presentation with sensitivity of 90 and specificity of 79. The cutoff value of the h score should be adapted. We launched a covid 19 resource center including a critical review of recommended calcs.

The baby with an undetermined diagnosis for whom hlh could not be formally excluded had an h score of 199 and met five of the six criteria of the adapted hlh 2004 guidelines. Table 2 the h score can be used to assess the likelihood of shlh in a patient. The diagnosis of hlh can be difficult due to the overlap with other hyperinflammatory syndromes sirs sepsis severe infection. Acknowledging this discrepancy fardet et al.

With a score of 169 the h score yielded a sensitivity and specificity of 93 and 86 respectively for the diagnosis of a hemophagocytic syndrome. The h score is a validated tool that predicts hlh with 90 accuracy using a cutoff of 169. For adults h score performances are better when determined at presentation. The adapted hlh 2004 guidelines seem less powerful and h score seems to be more appropriate for children which may be due to less significantly marked biological features.

Diagnoses reactive hemophagocytic syndrome. 13 14 the institutional review board reviewed this study and waived jurisdiction. This study was undertaken to develop and validate a diagnostic score for reactive hemophagocytic syndrome. Hscore for reactive hemophagocytic syndrome.